General Tumor Resection Synoptic Report — CAP elements with AJCC 9th Edition (auto stage)
Case / Specimen
Tumor / Macroscopic features
General AJCC 9 TNM guidance (tumor resection setting):
Note: The exact pT definitions are site-specific; below are general principles applicable across many solid tumors: - pT is based on size and/or depth of invasion into adjacent tissues and organs. For many sites, small, organ-confined tumors are lower pT (T1/T2), while invasion into adjacent structures, serosa, or through anatomic boundaries increases T category. - For soft tissue/visceral organs, record maximal dimension and whether tumor is confined to organ, invades local structures, or crosses fascial/serosal planes. - For tumors with organ-specific venous or neural invasion, document presence — this may alter T or overall staging per site-specific AJCC rules.
Always consult the AJCC site-specific pT definitions for precise assignment (e.g., lung, colon, head & neck, gynecologic).
Microscopic / Pathologic features
Regional lymph nodes
General AJCC 9 pN guidance: - pN0: No regional lymph node metastasis. - pN1 / pN2 / pN3: Defined by number, size, and location of regional nodal metastases; definitions vary by primary site (e.g., N1 single node vs N2 multiple regional nodes). - Document number of nodes examined, number positive, largest nodal deposit, extranodal extension, and nodal stations.
For exact pN assignment, use site-specific AJCC rules (regional vs non-regional nodal designations differ by primary tumor site).
Distant metastasis
General AJCC 9 pM guidance: - pM0: No pathologic evidence of distant metastasis. - pM1: Distant metastasis present (biopsy-proven when possible). Subclassification (M1a/b/c) depends on site (e.g., non-regional nodal, lung, bone, visceral). - Any pM1 = Stage IV by anatomic grouping. Document site(s), number of metastatic lesions, size, and method of confirmation (biopsy, surgical specimen, imaging).
AJCC 9 Stage Group Guidance (general)
General anatomic stage-group principles (site-specific tables required for final substaging): - Stage I–II: Typically smaller, organ-confined tumors (T1–T2) without nodal or distant metastasis. - Stage III: Locally advanced primary tumor (higher T) and/or regional nodal metastasis. - Stage IV: Tumor invades adjacent structures not resectable or any distant metastasis (M1).
Use AJCC site-specific tables to combine T, N, and M into precise stage groups and consider prognostic factors separately.